| Date / Division | Time | Home | Away | Referee |
| Premier | ||||
| 23/09/2021 | 8.00 | Garda | Templeogue | R Bradley |
| C Mc Carthy | ||||
| S McCall | ||||
| 24/09/2021 | 7.30 | Raheny Utd | Patricians | B Hand |
| S Dyas | ||||
| D O’Shea | ||||
| 25/09/2021 | 3.00 | Bluebell | Sheriff | B Coghlan |
| A North | ||||
| 25/09/2021 | 2.0 | Trinity Donaghmede | Rivervalley Rgs | |
| 25/09/2021 | 2.30 | Swords Cel | St Brendans Dingle | P Hughes |
| 25/09/2021 | 2.30 | Portmarnock | Real Transilvania | S Dyas |
| B North | ||||
| 24/09/2021 | 7.15 | St Brendans Dingle | Greenfield Pk | B Emerson |
| 25/09/2021 | 3.0 | Baldoyle Utd | Malahide Utd | C Dunne |
| C North | ||||
| 25/09/2021 | 2.00 | Celtic Pk | Ashbourne | R Bradley |
| 25/09/2021 | 3.00 | Vianney Boys | Marino | B Emerson |
| 25/09/2021 | 1.00 | Stoneybatter | Chanel SSC | B Emerson |
| D North | ||||
| 24/09/2021 | 7.45 | Coolock Village | Whitehall Rgs | P Hughes |
| 25/09/2021 | 2.00 | Rivervalley Rgs | St Ita’s | R Lynch |
| 25/09/2021 | 3.00 | Corduff | Super Friends | D O’Shea |
| 25/09/2021 | 2.00 | Swords Manor | Trinity Donaghmede | A Whelan |
| A South | ||||
| 25/09/2021 | 3.00 | Ballyoulster | Cottage | |
| 25/09/2021 | 3.00 | Alpine Oldchurch | Tymon Bawn | A Halligan |
| 24/09/2021 | 7.30 | Glenville | Cabinteely | R Bradley |
| B South | ||||
| 25/09/2021 | 2.30 | Walkinstown | St Anthonys | T Mc Kevitt |
| 25/09/2021 | 3.00 | Garden Co | Peamount Utd | Wicklow |
| 25/09/2021 | 2.00 | Larkview | Manortown | K Travers |
| C South | ||||
| 24/09/2021 | 7.00 | Booth Rd Cel | Lazio | M Lynch |
| 25/09/2021 | 2.30 | Tallaght Town | Blackforge | M Lynch |
| D South | ||||
| 24/09/2021 | 7.00 | Firhouse Carmel | Castle Cel/ Lourdes Cel | S McCall |
| 25/09/2021 | 2.00 | Pegasus/St James | Ballyfermot Utd | J Jackson |
| 25/09/2021 | 2.30 | OLV | DCT Utd | S McCall |
| 25/09/2021 | 1.00 | Palmerstown | Spartak Dynamo | A Karaczan |
| Sunday | ||||
| 26/09/2021 | 11.00 | Marks Cel | Portrane | M Doyle |
| 12/09/2021 | 12.00 | Sallynoggin Pearse | Markievitcz Cel | B Coghlan |